Part 25 Article: Biotechnology My Blog Title: The world, from the past to the present, retold from the timelines. Click on PDF to download from Part 3 2023: [10.23] The first successful transplant of a functional cryopreserved mammalian kidney was reported. The study demonstrated a "nano-warming" technique for vitrification for up-to-100 days preservation of transplant organs. Sourced from [frontiersin.org] titled: “Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts.” From the perspective of temperature, machine perfusion can be classified into four categories: HMP “hypothermic machine perfusion” (0°C to 12°C), MMP “mid-thermic machine perfusion” (13°C to 24°C), SNMP “subnormothermic machine perfusion” (25°C to 34°C), and NMP “normothermic machine perfusion” (35°C to 38°C). As metabolic activity increases exponentially with increasing temperature, the required amount of oxy...
Part 16 Article: Biotechnology My Blog Title: The world, from the past to the present, retold from the timelines. Click on PDF to download from Part 3 2023: Notable innovations: a large language model (ProGen) that could generate functional protein sequences with a predictable function, with the input including tags specifying protein properties. In linguistics, a corpus is a collection of linguistic data used for research, scholarship, and teaching. Indeed, even if different corpora existed to train protein language models, the correct interpretation of the produced sequences remains a challenge. Protein evolution differed from language evolution, containing irregularities due to randomness and environmental pressure, and with a grammar that unavoidably will contain many irregularities. Finally, we had to remark on the size of the language of proteins that needs to cover millions of species on Earth, which necessitated studying the general properties of proteins rather than study...