Part 22 The world, from the past to the present, retold from the timelines.

Part 22

Article: Biotechnology My Blog Title: The world, from the past to the present, retold from the timelines.

Click on PDF to download from Part 3

2023: [10.23] The first successful transplant of a functional cryopreserved mammalian kidney was reported. The study demonstrated a "nano-warming" technique for vitrification for up-to-100 days preservation of transplant organs. Sourced from [https://twin-cities.umn.edu] titled: “Researchers perform first successful transplant of functional cryopreserved rat kidney” Long-term organ banking could increase donor organ utilization, improve donor/recipient matching, enable immune tolerance protocols (reducing the need for immunosuppression drugs), and improve procedure preparation and scheduling. Immunosuppressants are drugs that prevent your immune system from attacking healthy cells and tissues by mistake. Immunosuppressant drugs suppress or reduce the strength of the immune system. Healthcare providers prescribe immunosuppressants to treat certain autoimmune diseases and prevent organ or stem cell transplant rejection. Importantly, while demonstrated in the kidney, this approach may one day be applied across transplant organs and also enable long-term storage of organs and tissue for biomedical and pharmacological research. The researchers had shown that all aspects of this approach could be scaled to larger organs and will next look to demonstrate the process using pig kidneys. While it will take several years before a cryopreserved organ will be transplanted into humans, the team was confident that it could successfully be done in the future. The research was primarily funded by the National Institutes of Health with additional support from the National Science Foundation and the Biostasis Research Institute which was funded in part through contributions from LifeGift, Nevada Donor Network, Lifesource, Donor Network West, and Lifebanc. About the research team: In addition to Bischof, Han, Rao, Finger, and Etheridge, the University of Minnesota research team included Lakshya Gangwar (mechanical engineering), Bat-Erdene Namsrai (surgery), Jacqueline L. Pasek-Allen (mechanical engineering and biomedical engineering), Susan M. Wolf (Consortium on Law and Values in Health, Environment & the Life Sciences), and Timothy L. Pruett (surgery). This research was part of a larger effort involving cryopreservation methods led by the University of Minnesota Twin Cities. In 2020, the University of Minnesota and Massachusetts General Hospital were awarded $26 million over five years from the National Science Foundation to create the Engineering Research Center (ERC) for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio). ATP-Bio aimed to achieve major bioengineering breakthroughs by developing and deploying the technology to stop biological time and biopreserve or cryopreserve numerous biological systems. ATP-Bio included 30 senior personnel and more than 80 trainees from seven institutions across the U.S. and Canada. Sourced from [frontiersin.org] titled: “Supercooling: a promising technique for prolonged preservation in solid organ transplantation, and early perspectives in vascularized composite allografts.” Vascularized Composite Allografts (VCAs) involve the transplantation of multiple structures that may include skin, bone, muscles, blood vessels, nerves and connective tissue. The most commonly known type of VCAs are for hand and face transplants.

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Picture sources: Peakpx.com and Pexels, Pixabay in PowerDirector and other websites:

1:https://cdnuploads.aa.com.tr/uploads/Contents/2019/12/11/thumbs_b_c_1dbd4044f469c88c0670d7055e1f4dd0.jpg?v=135921

2:https://www.swissinfo.ch/content/wp-content/uploads/sites/13/2024/09/515270225_highres.jpg?ver=b304ed09

3:https://www.science.org/content/article/how-to-deep-freeze-entire-organ-bring-it-back-to-life

4:https://www.researchgate.net/publication/371448058/figure/fig1/AS:11431281177801808@1690598967887/Overview-of-nanowarming-Depicted-are-the-sequential-steps-of-the-nanowarming-procedure-as.png

5:https://www.researchgate.net/publication/371448058/figure/fig7/AS:11431281177811839@1690598975036/Transplant-outcomes-of-nanowarmed-and-fresh-control-kidney-transplants-a-Depiction.png

6:https://www.science.org/cms/asset/e9fe4f90-d655-494d-b569-af7a8ec697ea/science.2023.380.issue-6652.largecover.jpg

7:https://www.frontiersin.org/files/Articles/1461480/fimmu-15-1461480-HTML/image_m/fimmu-15-1461480-g001.jpg