Part 36
Article: Biotechnology My Blog Title: The world, from the past to the present, retold from the timelines.
2023: Researchers reported a production method for spider silk fibers from gene-edited transgenic silkworms for a sustainable alternative material six times stronger than Kevlar. This type of fiber could be utilized as surgical sutures, addressing a global demand exceeding 300 million procedures annually. The spider silk fibers could also be used to create more comfortable garments and innovative types of bulletproof vests, said Mi, and they may have applications in smart materials, the military, aerospace technology, and biomedical engineering. To spin spider silk from silkworms, Mi and his team introduced spider silk protein genes into the DNA of silkworms so that it would be expressed in their glands using a combination of CRISPR-Cas9 gene editing technology and hundreds of thousands of microinjections into fertilized silkworm eggs. The microinjections posed "one of the most significant challenges" in the study, said Mi, but when he saw the silkworms' eyes glowing red under the fluorescence microscope, a sign that the gene editing had been successful; he was overjoyed. The researchers also needed to perform "localization" modifications on the transgenic spider silk proteins so that they would interact properly with proteins in the silkworm glands, ensuring that the fiber would be spun properly. To guide the modifications, the team developed a "minimal basic structure model" of silkworm silk." This concept of 'localization,' introduced in this thesis, along with the proposed minimal structural model, represented a significant departure from previous research, said Mi. "We are confident that large-scale commercialization is on the horizon.” In the future, Mi plans to use insights into the toughness and strength of spider silk fibers developed in the current study to develop genetically modified silkworms that produce spider silk fibers from both natural and engineered amino acids. The introduction of over one hundred engineered amino acids hold boundless potential for engineered spider silk fibers, said Mi. Silkworm silk was presently the only animal silk fiber commercialized on a large scale, with well-established rearing techniques, said Junpeng Mi, a PhD candidate at the College of Biological Science and Medical Engineering at Donghua University and the first author of the study. Consequently, employing genetically modified silkworms to produce spider silk fiber enabled low-cost, large-scale commercialization.
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Music Sources and Titles: Pixabay
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Picture sources: Peakpx.com and Pexels, Pixabay in PowerDirector and other websites:
1:https://media.techeblog.com/images/dragon-silk-spider-silk-body-armor.jpg
2:https://scitechdaily.com/images/Spider-Webs-Strength-Lies-in-More-Than-Its-Silk-768x1199.jpg
10:https://phys.org/news/2023-09-spider-silk-spun-silkworms-green.amp
11:https://images.threadsmagazine.com/app/uploads/2021/05/09144015/Stephanie2-1-1.png
14:https://www.tuat.ac.jp/images/tuat/department/engineering/bme/IMG_BME4.jpg
16:https://cdn-blog.adafruit.com/uploads/2016/07/dragonsilk-1.jpg
19:https://www.botanicplanet.ca/image/cache/catalog/Product/Hydrolysedsilkproteinpowder-500x500.jpg
20:https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e9/5733852/c0e95304da01/yjbm_90_4_599_g02.jpg
22:https://prod-shared-star-protocols.s3.amazonaws.com/protocols/1477-GA.jpg
23:https://wedushare.com/_next/image?url=%2Fuploads%2FDonghua_University_4aa44b3c91.jpg&w=750&q=75
25:https://www.pandasilk.com/wp-content/uploads/2017/01/Silk-Fabric-Production-Process.jpg
Video Sources: Pexels and Pixabay in PowerDirector and other websites:
26:https://www.pond5.com/stock-footage/item/306518178-dna-double-helix-structure-black-background
27:https://www.pond5.com/stock-footage/item/306518172-dna-double-helix-structure-black-background
30:https://www.pond5.com/stock-footage/item/178537734-crispr-cas-9-cutting-dna
31:https://www.pond5.com/stock-footage/item/47863320-3d-background-rotating-dna-string-4k-ultra-hd
32:https://www.pond5.com/stock-footage/item/374264-dna
33:https://www.pond5.com/stock-footage/item/289604104-double-helix-structure-dna-strand
34:https://www.pond5.com/stock-footage/item/242951374-dna-double-helix-molecule
36:https://www.pond5.com/stock-footage/item/56805002-selection-eggs-petri-dish-under-microscope-close
37:https://www.pond5.com/stock-footage/item/74368395-surgical-forceps-holding-suture-needle-slow-motion
38:https://www.pond5.com/stock-footage/item/149974205-summer-foggy-morning-diadem-spider-center-dew-web
42:https://www.pond5.com/stock-footage/item/74201582-yarn-factory-loom-working
43:https://www.pond5.com/stock-footage/item/60594935-silkworm-moth-larvae-eggs
44:https://www.pond5.com/stock-footage/item/68289977-futuristic-rotating-dna-binary-genetic-information
45:https://www.pond5.com/stock-footage/item/178539064-crispr-cas-9-cutting-dna
46:https://www.pond5.com/stock-footage/item/154668389-progress-mature-silkworm-shed-its-skin
47:https://www.pond5.com/stock-footage/item/309319888-silkworm-weaves-silk-webs
Consulted References:
Refer to Part 3 for all consolidated references for all parts.


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